Past or present history of venous thrombosis (deep vein thrombosis, pulmonary embolism).

Past or present history of arterial thrombosis (e.g. stroke, heart attack) or related manifestations (e.g. angina pectoris or temporary circulatory disturbances in the brain, which can be indicated by transient impairment of vision, for example).

Presence of one or more severe risk factors for arterial thrombosis: diabetes with vascular changes, severe hypertension, severe disorders of lipid metabolism.

Inherited or acquired disposition to venous or arterial thrombosis such as APC resistance, antithrombin III deficiency.

Past or present history of severe liver disease until the liver function values have returned to normal.

Past or present history of liver tumors (benign or malignant).

Known or suspected malignant diseases of the genital organs or the breasts if these are influenced by sex hormones.

Unexplained vaginal bleeding.

History of migraine with focal neurological symptoms.

Hypersensitivity to any of the active ingredients of the preparation.

Smoking

Diabetes

Significant overweight

High blood pressure

Diseases of the heart valves or certain cardiac rhythm disorders

Inflammation of the veins (superficial phlebitis)

Varicose veins

Thrombosis, heart attack or stroke in close relatives

Migraine

Epilepsy

High blood fat levels (cholesterol or triglycerides) or close relatives with high blood fat levels

Breast cancer in a close relative

Liver or gall bladder diseases

Chronic bowel disease (Crohn's disease or ulcerative colitis)

Systemic lupus erythematosus (a disease of the immune system)

Hemolytic-uremic syndrome (a blood disease that causes kidney damage)

Patchy, yellowish-brown discoloration of the skin, particularly of the face, or occurrence during a previous pregnancy (chloasma). In this case prolonged exposure to sunlight and UV radiation should be avoided.